Ontology highlight
ABSTRACT:
SUBMITTER: Bording S
PROVIDER: S-EPMC3254509 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Acta crystallographica. Section E, Structure reports online 20111217 Pt 1
The title compound, C(19)H(24)ClNO(5), was synthesized and subsequently employed in an Evans alkyl-ation. The purpose was to prove the absolute configuration in the projected synthesis of the side chain of (-)-Lytophilippine A. The oxazolidinone and the isopropylidene acetal rings have twisted conformations. The oxazolidinone and side-chain carbonyl groups are orientated in an anti-periplanar arrangement to minimize van der Waals repulsions. Furthermore, the Cl atom and the acetonide-protected s ...[more]