Delivery of MicroRNA-10b with Polylysine Nanoparticles for Inhibition of Breast Cancer Cell Wound Healing.
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ABSTRACT:
SUBMITTER: Jin H
PROVIDER: S-EPMC3256732 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Delivery of MicroRNA-10b with Polylysine Nanoparticles for Inhibition of Breast Cancer Cell Wound Healing.
Jin Hongjun H Yu Yuehua Y Chrisler William B WB Xiong Yijia Y Hu Dehong D Lei Chenghong C
Breast cancer : basic and clinical research 20111207
Recent studies revealed that micro RNA-10b (mir-10b) is highly expressed in metastatic breast cancer cells and positively regulates breast cancer cell migration and invasion through inhibition of HOXD10 target synthesis. In this study we designed anti-mir-10b molecules and combined them with poly L-lysine (PLL) to test the delivery effectiveness. An RNA molecule sequence exactly matching the mature mir-10b minor antisense showed strong inhibition when mixed with PLL in a wound-healing assay with ...[more]
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