Ontology highlight
ABSTRACT:
SUBMITTER: Xie T
PROVIDER: S-EPMC3259534 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Xie Tao T Graveline Richard R Kumar Ganesan Senthil GS Zhang Yongbo Y Krishnan Arvind A David Gregory G Radhakrishnan Ishwar I
Structure (London, England : 1993) 20120101 1
MRG15 is a member of the mortality family of transcription factors that targets a wide variety of multiprotein complexes involved in transcription regulation, DNA repair, and alternative splicing to chromatin. The structure of the apo-MRG15 MRG domain implicated in interactions with diverse proteins has been described, but not in complex with any of its targets. Here, we structurally and functionally characterize the interaction between MRG15 and Pf1, two constitutively associated subunits of th ...[more]