Ontology highlight
ABSTRACT:
SUBMITTER: Suthana NA
PROVIDER: S-EPMC3260048 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Suthana Nanthia A NA Krupa Allison A Donix Markus M Burggren Alison A Ekstrom Arne D AD Jones Michael M Ercoli Linda M LM Miller Karen J KJ Siddarth Prabha P Small Gary W GW Bookheimer Susan Y SY
NeuroImage 20091218 3
Previous functional magnetic resonance imaging (MRI) studies in healthy subjects with the apolipoprotein Eepsilon4 (APOE-4) genetic risk for Alzheimer's disease have shown increased activation during memory task performance in broadly distributed cortical regions. These findings have been hypothesized to reflect compensatory recruitment of intact brain regions that presumably result from subtle neural dysfunction reflecting incipient disease. In this study, we used high-resolution functional MRI ...[more]