Ontology highlight
ABSTRACT:
SUBMITTER: Budin I
PROVIDER: S-EPMC3262119 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Budin Itay I Devaraj Neal K NK
Journal of the American Chemical Society 20111229 2
One of the major goals of synthetic biology is the development of non-natural cellular systems. In this work, we describe a catalytic biomimetic coupling reaction capable of driving the de novo self-assembly of phospholipid membranes. Our system features a coppercatalyzed azide-alkyne cycloaddition that results in the formation of a triazole-containing phospholipid analogue. Concomitant assembly of membranes occurs spontaneously, not requiring preexisting membranes to house catalysts or precurso ...[more]