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Membrane assembly driven by a biomimetic coupling reaction.

ABSTRACT: One of the major goals of synthetic biology is the development of non-natural cellular systems. In this work, we describe a catalytic biomimetic coupling reaction capable of driving the de novo self-assembly of phospholipid membranes. Our system features a coppercatalyzed azide-alkyne cycloaddition that results in the formation of a triazole-containing phospholipid analogue. Concomitant assembly of membranes occurs spontaneously, not requiring preexisting membranes to house catalysts or precursors. The substitution of efficient synthetic reactions for key biochemical processes may offer a general route toward synthetic biological systems.

SUBMITTER: Budin I

PROVIDER: S-EPMC3262119 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature

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Membrane assembly driven by a biomimetic coupling reaction.

Budin Itay I Devaraj Neal K NK

Journal of the American Chemical Society 20111229 2

One of the major goals of synthetic biology is the development of non-natural cellular systems. In this work, we describe a catalytic biomimetic coupling reaction capable of driving the de novo self-assembly of phospholipid membranes. Our system features a coppercatalyzed azide-alkyne cycloaddition that results in the formation of a triazole-containing phospholipid analogue. Concomitant assembly of membranes occurs spontaneously, not requiring preexisting membranes to house catalysts or precurso ...[more]

PMID: 22239722

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