Ontology highlight
ABSTRACT:
SUBMITTER: Janbazian L
PROVIDER: S-EPMC3262882 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Janbazian Loury L Price David A DA Canderan Glenda G Filali-Mouhim Abdelali A Asher Tedi E TE Ambrozak David R DR Scheinberg Phillip P Boulassel Mohamad Rachid MR Routy Jean-Pierre JP Koup Richard A RA Douek Daniel C DC Sekaly Rafick-Pierre RP Trautmann Lydie L
Journal of immunology (Baltimore, Md. : 1950) 20111230 3
Persistent exposure to cognate Ag leads to the functional impairment and exhaustion of HIV-specific CD8 T cells. Ag withdrawal, attributable either to antiretroviral treatment or the emergence of epitope escape mutations, causes HIV-specific CD8 T cell responses to wane over time. However, this process does not continue to extinction, and residual CD8 T cells likely play an important role in the control of HIV replication. In this study, we conducted a longitudinal analysis of clonality, phenoty ...[more]