Ontology highlight
ABSTRACT:
SUBMITTER: Melzer BC
PROVIDER: S-EPMC6774065 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Beilstein journal of organic chemistry 20190926
Readily available 4-bromobenzo[<i>c</i>][2,7]naphthyridine undergoes regioselective direct ring metalation at C-5 with TMPMgCl∙LiCl at -40 °C. Quenching with various electrophiles gives a broad range of 5-substituted products, which are building blocks for the synthesis of heterocyclic natural products and analogues thereof. In combination with a Parham-type cyclization a novel approach to pyrido[4,3,2-<i>mn</i>]acridones has been worked out. ...[more]