Ontology highlight
ABSTRACT:
SUBMITTER: Puga I
PROVIDER: S-EPMC3262910 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Puga Irene I Cols Montserrat M Barra Carolina M CM He Bing B Cassis Linda L Gentile Maurizio M Comerma Laura L Chorny Alejo A Shan Meimei M Xu Weifeng W Magri Giuliana G Knowles Daniel M DM Tam Wayne W Chiu April A Bussel James B JB Serrano Sergi S Lorente José Antonio JA Bellosillo Beatriz B Lloreta Josep J Juanpere Nuria N Alameda Francesc F Baró Teresa T de Heredia Cristina Díaz CD Torán Núria N Català Albert A Torrebadell Montserrat M Fortuny Claudia C Cusí Victoria V Carreras Carmen C Diaz George A GA Blander J Magarian JM Farber Claire-Michèle CM Silvestri Guido G Cunningham-Rundles Charlotte C Calvillo Michaela M Dufour Carlo C Notarangelo Lucia Dora LD Lougaris Vassilios V Plebani Alessandro A Casanova Jean-Laurent JL Ganal Stephanie C SC Diefenbach Andreas A Aróstegui Juan Ignacio JI Juan Manel M Yagüe Jordi J Mahlaoui Nizar N Donadieu Jean J Chen Kang K Cerutti Andrea A
Nature immunology 20111225 2
Neutrophils use immunoglobulins to clear antigen, but their role in immunoglobulin production is unknown. Here we identified neutrophils around the marginal zone (MZ) of the spleen, a B cell area specialized in T cell-independent immunoglobulin responses to circulating antigen. Neutrophils colonized peri-MZ areas after postnatal mucosal colonization by microbes and enhanced their B cell-helper function after receiving reprogramming signals, including interleukin 10 (IL-10), from splenic sinusoid ...[more]