Ontology highlight
ABSTRACT:
SUBMITTER: Bryson DI
PROVIDER: S-EPMC3262918 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
ACS chemical biology 20111028 1
Rational design of RNA ligands continues to be a formidable challenge, but the potential powerful applications in biology and medicine catapults it to the forefront of chemical research. Indeed, small molecule and macromolecular intervention are attractive approaches, but selectivity and cell permeability can be a hurdle. An alternative strategy is to use molecules of intermediate molecular weight that possess large enough surface area to maximize interaction with the RNA structure but are small ...[more]