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Thiomyristoyl peptides as cell-permeable Sirt6 inhibitors.

ABSTRACT: Sirtuins regulate a variety of biological pathways and inhibitors of sirtuins have been actively pursued as tool compounds to study sirtuin biology and as potential therapeutics. Here we demonstrate that thiomyristoyl peptides are potent and cell-permeable inhibitors of Sirt6, one of the seven human sirtuins, and will serve as the starting point for the development of more specific Sirt6 inhibitors.

SUBMITTER: He B

PROVIDER: S-EPMC4161628 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

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Thiomyristoyl peptides as cell-permeable Sirt6 inhibitors.

He Bin B Hu Jing J Zhang Xiaoyu X Lin Hening H

Organic & biomolecular chemistry 20141001 38

Sirtuins regulate a variety of biological pathways and inhibitors of sirtuins have been actively pursued as tool compounds to study sirtuin biology and as potential therapeutics. Here we demonstrate that thiomyristoyl peptides are potent and cell-permeable inhibitors of Sirt6, one of the seven human sirtuins, and will serve as the starting point for the development of more specific Sirt6 inhibitors. ...[more]

PMID: 25163004

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