Ontology highlight
ABSTRACT:
SUBMITTER: Fudenberg G
PROVIDER: S-EPMC3268007 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Nature biotechnology 20111120 12
The accumulation of data on structural variation in cancer genomes provides an opportunity to better understand the mechanisms of genomic alterations and the forces of selection that act upon these alterations in cancer. Here we test evidence supporting the influence of two major forces, spatial chromosome structure and purifying (or negative) selection, on the landscape of somatic copy-number alterations (SCNAs) in cancer. Using a maximum likelihood approach, we compare SCNA maps and three-dime ...[more]