Ribosomal route to small-molecule diversity.
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ABSTRACT:
SUBMITTER: Tianero MD
PROVIDER: S-EPMC3268757 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Publications
Ribosomal route to small-molecule diversity.
Tianero Ma Diarey B MD Donia Mohamed S MS Young Travis S TS Schultz Peter G PG Schmidt Eric W EW
Journal of the American Chemical Society 20111222 1
The cyanobactin ribosomal peptide (RP) natural product pathway was manipulated to incorporate multiple tandem mutations and non-proteinogenic amino acids, using eight heterologous components simultaneously expressed in Escherichia coli . These studies reveal the potential of RPs for the rational synthesis of complex, new small molecules over multiple-step biosynthetic pathways using simple genetic engineering. ...[more]
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