Ontology highlight
ABSTRACT:
SUBMITTER: Hayakawa Y
PROVIDER: S-EPMC4684751 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Cancer cell 20151112 6
The regulation and stem cell origin of normal and neoplastic gastric glands are uncertain. Here, we show that Mist1 expression marks quiescent stem cells in the gastric corpus isthmus. Mist1(+) stem cells serve as a cell-of-origin for intestinal-type cancer with the combination of Kras and Apc mutation and for diffuse-type cancer with the loss of E-cadherin. Diffuse-type cancer development is dependent on inflammation mediated by Cxcl12(+) endothelial cells and Cxcr4(+) gastric innate lymphoid c ...[more]