Ontology highlight
ABSTRACT:
SUBMITTER: Zou JX
PROVIDER: S-EPMC2084297 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Zou June X JX Revenko Alexey S AS Li Li B LB Gemo Abigael T AT Chen Hong-Wu HW
Proceedings of the National Academy of Sciences of the United States of America 20071112 46
AAA+ proteins play crucial roles in diverse biological processes via their ATPase-driven remodeling of macromolecular complexes. Here we report our identification of an evolutionarily conserved AAA+ protein, ANCCA/pro2000, endowed with a bromodomain that is strongly induced by estrogen in human breast cancer cells and is a direct target of protooncogene ACTR/AIB1/SRC-3. We found that ANCCA associates directly with estrogen-bound estrogen receptor (ER) alpha and ACTR. It is selectively recruited, ...[more]