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Xenopus paraxial protocadherin inhibits Wnt/?-catenin signalling via casein kinase 2?.

ABSTRACT: Xenopus paraxial protocadherin (PAPC) regulates cadherin-mediated cell adhesion and promotes the planar cell polarity (PCP) pathway. Here we report that PAPC functions in the Xenopus gastrula as an inhibitor of the Wnt/?-catenin pathway. The intracellular domain of PAPC interacts with casein kinase 2 beta (CK2?), which is part of the CK2 holoenzyme. The CK2?/? complex stimulates Wnt/?-catenin signalling, and the physical interaction of CK2? with PAPC antagonizes this activity. By this mechanism, PAPC restricts the expression of Wnt target genes during gastrulation. These experiments identify a novel function of protocadherins as regulators of the Wnt pathway.

SUBMITTER: Kietzmann A

PROVIDER: S-EPMC3271334 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

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Xenopus paraxial protocadherin inhibits Wnt/β-catenin signalling via casein kinase 2β.

Kietzmann Anja A Wang Yingqun Y Weber Dominik D Steinbeisser Herbert H

EMBO reports 20120201 2

Xenopus paraxial protocadherin (PAPC) regulates cadherin-mediated cell adhesion and promotes the planar cell polarity (PCP) pathway. Here we report that PAPC functions in the Xenopus gastrula as an inhibitor of the Wnt/β-catenin pathway. The intracellular domain of PAPC interacts with casein kinase 2 beta (CK2β), which is part of the CK2 holoenzyme. The CK2α/β complex stimulates Wnt/β-catenin signalling, and the physical interaction of CK2β with PAPC antagonizes this activity. By this mechanism, ...[more]

PMID: 22193776

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