Ontology highlight
ABSTRACT:
SUBMITTER: Medina A
PROVIDER: S-EPMC514504 | biostudies-literature | 2004 Aug
REPOSITORIES: biostudies-literature
Medina Araceli A Swain Rajeeb K RK Kuerner Klaus-Michael KM Steinbeisser Herbert H
The EMBO journal 20040722 16
Protocadherins have homophilic adhesion properties and mediate selective cell-cell adhesion and cell sorting. Knockdown of paraxial protocadherin (PAPC) function in the Xenopus embryo impairs tissue separation, a process that regulates separation of cells of ectodermal and mesodermal origin during gastrulation. We show that PAPC can modulate the activity of the Rho GTPase and c-jun N-terminal kinase, two regulators of the cytoskeletal architecture and effectors of the planar cell polarity pathwa ...[more]