Ontology highlight
ABSTRACT:
SUBMITTER: Samarakoon TB
PROVIDER: S-EPMC3271938 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Organic letters 20110907 19
A reaction pairing strategy centered on utilization of a reaction triad (sulfonylation, S(N)Ar addition and Mitsunobu alkylation) generating skeletally diverse, tricyclic and bicyclic benzofused sultams is reported. Pairing sulfonylation and S(N)Ar reactions yields bridged, tricyclic and bicyclic benzofused sultams. Application of the Mitsunobu reaction in a sulfonylation-Mitsunobu-S(N)Ar pairing allows access to benzthiazocine-1,1-dioxides, while a simple change in the order of pairing to sulfo ...[more]