Ontology highlight
ABSTRACT:
SUBMITTER: Loh JK
PROVIDER: S-EPMC3458752 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Loh Joanna K JK Yoon Sun Young SY Samarakoon Thiwanka B TB Rolfe Alan A Porubsky Patrick P Neuenswander Benjamin B Lushington Gerald H GH Hanson Paul R PR
Beilstein journal of organic chemistry 20120815
The efficient synthesis of an 80-member library of unique benzoxathiazocine 1,1-dioxides by a microwave-assisted, intermolecular nucleophilic aromatic substitution (S(N)Ar) diversification pathway is reported. Eight benzofused sultam cores were generated by means of a sulfonylation/S(N)Ar/Mitsunobu reaction pairing protocol, and subsequently diversified by intermolecular S(N)Ar with ten chiral, non-racemic amine/amino alcohol building blocks. Computational analyses were employed to explore and e ...[more]