Ontology highlight
ABSTRACT:
SUBMITTER: Salvati AE
PROVIDER: S-EPMC6009507 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Chemical science 20180525 24
A 5-8-5 carbocyclic ring system forms the core of over 30 distinct natural products. Several members of this family have gained attention for their diverse activity in cell culture. In these cases, biological function is mediated by the arrangement of substituents around a conserved 5-8-5 nucleus. Despite the potential applications of this privileged substructure in medicinal chemistry, modular strategies for its assembly are underdeveloped. Herein, we describe a cycloisomerization reaction that ...[more]