Ontology highlight
ABSTRACT:
SUBMITTER: Silberberg Y
PROVIDER: S-EPMC3272249 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Silberberg Yael Y Gottlieb Assaf A Kupiec Martin M Ruppin Eytan E Sharan Roded R
Journal of computational biology : a journal of computational molecular cell biology 20120201 2
Elucidating signaling pathways is a fundamental step in understanding cellular processes and developing new therapeutic strategies. Here we introduce a method for the large-scale elucidation of signaling pathways involved in cellular response to drugs. Combining drug targets, drug response expression profiles, and the human physical interaction network, we infer 99 human drug response pathways and study their properties. Based on the newly inferred pathways, we develop a pathway-based drug-drug ...[more]