Ontology highlight
ABSTRACT:
SUBMITTER: Beran RK
PROVIDER: S-EPMC3275588 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Beran Rudolf K F RK Sharma Ruchi R Corsa Amoreena C AC Tian Yang Y Golde Justin J Lundgaard Greta G Delaney William E WE Zhong Weidong W Greenstein Andrew E AE
PloS one 20120208 2
During antiviral drug discovery, it is critical to distinguish molecules that selectively interrupt viral replication from those that reduce virus replication by adversely affecting host cell viability. In this report we investigate the selectivity of inhibitors of the host chaperone proteins cyclophilin A (CypA) and heat-shock protein 90 (HSP90) which have each been reported to inhibit replication of hepatitis C virus (HCV). By comparing the toxicity of the HSP90 inhibitor, 17-(Allylamino)-17-d ...[more]