Ontology highlight
ABSTRACT:
SUBMITTER: Koirala D
PROVIDER: S-EPMC3277938 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Koirala Deepak D Dhakal Soma S Ashbridge Beth B Sannohe Yuta Y Rodriguez Raphaël R Sugiyama Hiroshi H Balasubramanian Shankar S Mao Hanbin H
Nature chemistry 20110828 10
Ligands that stabilize the formation of telomeric DNA G-quadruplexes have potential as cancer treatments, because the G-quadruplex structure cannot be extended by telomerase, an enzyme over-expressed in many cancer cells. Understanding the kinetic, thermodynamic and mechanical properties of small-molecule binding to these structures is therefore important, but classical ensemble assays are unable to measure these simultaneously. Here, we have used a laser tweezers method to investigate such inte ...[more]