Dataset Information

Association of leisure-time physical activity with cognition by apolipoprotein-E genotype in persons aged 60 years and over: the National Health and Nutrition Examination Survey (NHANES-III).

ABSTRACT:

Objective

To test the hypothesis that aerobic-related leisure-time physical activity (PA) is associated with better cognitive function and that the effect varies among apolipoprotein E (APOE) genotype groups.

Design

Cross-sectional study of persons examined in the Third National Health and Nutrition Examination Survey (NHANES-III; 1988-1994).

Setting

US noninstitutionalized population.

Participants and methods

From a sample of 7159, aged ?60 years, we analyzed data for 1799 older American men and women who had information on PA, a short mental status examination (SMSE), and were genotyped at the apolipoprotein E gene locus.

Results

In the initial bivariate analysis, non-?4 carriers and ?4-heterozygotes performed better than ?4-homozygotes in the 60-69 age group. After controlling for multiple confounders including mobility limitation, PA correlated with a higher SMSE score in non-?4 carriers (P = 0.014), but not in ?4 carriers (P = 0.887). At ?70 years, PA also correlated with higher adjusted SMSE scores in non-?4 carriers (P = 0.02); but this association became nonsignificant after controlling for mobility limitation (P = 0.12).

Conclusion

In a nationally representative sample, PA was associated with enhanced cognition, an effect that was differentially influenced by apolipoprotein E genotype. Experimental studies are needed to determine whether or not PA can attenuate cognitive decline.

SUBMITTER: Obisesan TO

PROVIDER: S-EPMC3278197 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Association of leisure-time physical activity with cognition by apolipoprotein-E genotype in persons aged 60 years and over: the National Health and Nutrition Examination Survey (NHANES-III).

Obisesan Thomas O TO Umar Nisser N Paluvoi Nivedh N Gillum Richard F RF

Clinical interventions in aging 20120131

<h4>Objective</h4>To test the hypothesis that aerobic-related leisure-time physical activity (PA) is associated with better cognitive function and that the effect varies among apolipoprotein E (APOE) genotype groups.<h4>Design</h4>Cross-sectional study of persons examined in the Third National Health and Nutrition Examination Survey (NHANES-III; 1988-1994).<h4>Setting</h4>US noninstitutionalized population.<h4>Participants and methods</h4>From a sample of 7159, aged ≥60 years, we analyzed data f ...[more]

PMID: 22334766

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Dataset Information

Association of leisure-time physical activity with cognition by apolipoprotein-E genotype in persons aged 60 years and over: the National Health and Nutrition Examination Survey (NHANES-III).

Objective

Design

Setting

Participants and methods

Results

Conclusion

Publications

Association of leisure-time physical activity with cognition by apolipoprotein-E genotype in persons aged 60 years and over: the National Health and Nutrition Examination Survey (NHANES-III).

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