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Aneuploidy drives genomic instability in yeast.

ABSTRACT: Aneuploidy decreases cellular fitness, yet it is also associated with cancer, a disease of enhanced proliferative capacity. To investigate one mechanism by which aneuploidy could contribute to tumorigenesis, we examined the effects of aneuploidy on genomic stability. We analyzed 13 budding yeast strains that carry extra copies of single chromosomes and found that all aneuploid strains exhibited one or more forms of genomic instability. Most strains displayed increased chromosome loss and mitotic recombination, as well as defective DNA damage repair. Aneuploid fission yeast strains also exhibited defects in mitotic recombination. Aneuploidy-induced genomic instability could facilitate the development of genetic alterations that drive malignant growth in cancer.

SUBMITTER: Sheltzer JM

PROVIDER: S-EPMC3278960 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature

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Aneuploidy drives genomic instability in yeast.

Sheltzer Jason M JM Blank Heidi M HM Pfau Sarah J SJ Tange Yoshie Y George Benson M BM Humpton Timothy J TJ Brito Ilana L IL Hiraoka Yasushi Y Niwa Osami O Amon Angelika A

Science (New York, N.Y.) 20110801 6045

Aneuploidy decreases cellular fitness, yet it is also associated with cancer, a disease of enhanced proliferative capacity. To investigate one mechanism by which aneuploidy could contribute to tumorigenesis, we examined the effects of aneuploidy on genomic stability. We analyzed 13 budding yeast strains that carry extra copies of single chromosomes and found that all aneuploid strains exhibited one or more forms of genomic instability. Most strains displayed increased chromosome loss and mitotic ...[more]

PMID: 21852501

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2018-03-21 | GSE112062 | GEO

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