MYO10 drives genomic instability and inflammation in cancer.
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ABSTRACT:
SUBMITTER: Mayca Pozo F
PROVIDER: S-EPMC8443186 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Publications
MYO10 drives genomic instability and inflammation in cancer.
Mayca Pozo Franklin F Geng Xinran X Tamagno Ilaria I Jackson Mark W MW Heimsath Ernest G EG Hammer John A JA Cheney Richard E RE Zhang Youwei Y
Science advances 20210915 38
Genomic instability is a hallmark of human cancer; yet the underlying mechanisms remain poorly understood. Here, we report that the cytoplasmic unconventional Myosin X (MYO10) regulates genome stability, through which it mediates inflammation in cancer. MYO10 is an unstable protein that undergoes ubiquitin-conjugating enzyme H7 (UbcH7)/β-transducin repeat containing protein 1 (β-TrCP1)–dependent degradation. MYO10 is upregulated in both human and mouse tumors and its expression level predisposes ...[more]
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