Unknown

Dataset Information

0

Innate response activator B cells protect against microbial sepsis.


ABSTRACT: Recognition and clearance of a bacterial infection are a fundamental properties of innate immunity. Here, we describe an effector B cell population that protects against microbial sepsis. Innate response activator (IRA) B cells are phenotypically and functionally distinct, develop and diverge from B1a B cells, depend on pattern-recognition receptors, and produce granulocyte-macrophage colony-stimulating factor. Specific deletion of IRA B cell activity impairs bacterial clearance, elicits a cytokine storm, and precipitates septic shock. These observations enrich our understanding of innate immunity, position IRA B cells as gatekeepers of bacterial infection, and identify new treatment avenues for infectious diseases.

SUBMITTER: Rauch PJ 

PROVIDER: S-EPMC3279743 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications


Recognition and clearance of a bacterial infection are a fundamental properties of innate immunity. Here, we describe an effector B cell population that protects against microbial sepsis. Innate response activator (IRA) B cells are phenotypically and functionally distinct, develop and diverge from B1a B cells, depend on pattern-recognition receptors, and produce granulocyte-macrophage colony-stimulating factor. Specific deletion of IRA B cell activity impairs bacterial clearance, elicits a cytok  ...[more]

Similar Datasets

2012-02-07 | E-GEOD-32372 | biostudies-arrayexpress
2012-02-07 | GSE32372 | GEO
| S-EPMC5840374 | biostudies-literature
| S-EPMC10124078 | biostudies-literature
| S-EPMC10245321 | biostudies-literature
| S-EPMC5997389 | biostudies-literature
| S-EPMC7867134 | biostudies-literature
| S-EPMC7781629 | biostudies-literature
| S-EPMC3997655 | biostudies-literature
| S-EPMC4595134 | biostudies-literature