Ontology highlight
ABSTRACT:
SUBMITTER: Rauch PJ
PROVIDER: S-EPMC3279743 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Rauch Philipp J PJ Chudnovskiy Aleksey A Robbins Clinton S CS Weber Georg F GF Etzrodt Martin M Hilgendorf Ingo I Tiglao Elizabeth E Figueiredo Jose-Luiz JL Iwamoto Yoshiko Y Theurl Igor I Gorbatov Rostic R Waring Michael T MT Chicoine Adam T AT Mouded Majd M Pittet Mikael J MJ Nahrendorf Matthias M Weissleder Ralph R Swirski Filip K FK
Science (New York, N.Y.) 20120112 6068
Recognition and clearance of a bacterial infection are a fundamental properties of innate immunity. Here, we describe an effector B cell population that protects against microbial sepsis. Innate response activator (IRA) B cells are phenotypically and functionally distinct, develop and diverge from B1a B cells, depend on pattern-recognition receptors, and produce granulocyte-macrophage colony-stimulating factor. Specific deletion of IRA B cell activity impairs bacterial clearance, elicits a cytok ...[more]