Polymeric nanomaterials for islet targeting and immunotherapeutic delivery.
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ABSTRACT:
SUBMITTER: Ghosh K
PROVIDER: S-EPMC3280082 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Publications
Polymeric nanomaterials for islet targeting and immunotherapeutic delivery.
Ghosh Kaustabh K Kanapathipillai Mathumai M Korin Netanel N McCarthy Jason R JR Ingber Donald E DE
Nano letters 20111228 1
Here we report a proof-of-concept for development of pancreatic islet-targeting nanoparticles for immunomodulatory therapy of autoimmune type 1 diabetes. Modified with a unique islet-homing peptide, these polymeric nanomaterials exhibit 3-fold greater binding to islet endothelial cells and a 200-fold greater anti-inflammatory effect through targeted islet endothelial cell delivery of an immunosuppressant drug. Our findings also underscore the need to carefully tailor drug loading and nanoparticl ...[more]
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