Ontology highlight
ABSTRACT:
SUBMITTER: Dubrovska A
PROVIDER: S-EPMC3281066 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
PloS one 20120216 2
Tumor progenitor cells represent a population of drug-resistant cells that can survive conventional chemotherapy and lead to tumor relapse. However, little is known of the role of tumor progenitors in prostate cancer metastasis. The studies reported herein show that the CXCR4/CXCL12 axis, a key regulator of tumor dissemination, plays a role in the maintenance of prostate cancer stem-like cells. The CXCL4/CXCR12 pathway is activated in the CD44(+)/CD133(+) prostate progenitor population and affec ...[more]