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Gene expression pattern in CXCR4+ and CXCR4- subpopulation of breast cancer cells


ABSTRACT: The goal of this study was to identify signalling molecules downstream of CXCR4 in breast cancer cells. For this purpose, we sorted CXCR4-positive and CXCR4-negative cells from MDA-MB-231 breast cancer cell line by flow cytometry and performed microarrays analysis. Three sets of samples, each in quadruplicate, were analyzed. These include CXCR4-positive subpopulation, CXCR4-positive subpopulation treated with SDF-1 (ligand for CXCR4, also called CXCL12) for one hour and CXCR4-negative subpopulation.

ORGANISM(S): Homo sapiens

SUBMITTER: Appaiah H 

PROVIDER: S-ECPF-GEOD-15893 | biostudies-other | 2010 Sep

REPOSITORIES: biostudies-other

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