Ontology highlight
ABSTRACT:
SUBMITTER: Astashkin AV
PROVIDER: S-EPMC3288158 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Astashkin Andrei V AV Rajapakshe Asha A Cornelison Matthew J MJ Johnson-Winters Kayunta K Enemark John H JH
The journal of physical chemistry. B 20120203 6
Intramolecular electron transfer (IET) between the molybdenum and heme centers of vertebrate sulfite oxidase (SO) is proposed to be a key step in the catalytic cycle of the enzyme. However, the X-ray crystallographic distance between these centers, R(MoFe) = 32.3 Å, appears to be too long for the rapid IET rates observed in liquid solution. The Mo and heme domains are linked by a flexible tether, and it has been proposed that dynamic interdomain motion brings the two metal centers closer togethe ...[more]