Ontology highlight
ABSTRACT:
SUBMITTER: Yue T
PROVIDER: S-EPMC3288783 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Yue Tao T Tian Aiguo A Jiang Jin J
Developmental cell 20120125 2
The Hippo (Hpo) signaling pathway controls tissue growth and organ size in species ranging from Drosophila to mammals and is deregulated in a wide range of human cancers. The core pathway consists of the Hpo/Warts (Wts) kinase cassette that phosphorylates and inactivates the transcriptional coactivator Yorkie (Yki). Here, we report that Echinoid (Ed), an immunoglobulin domain-containing cell adhesion molecule, acts as an upstream regulator of the Hpo pathway. Loss of Ed compromises Yki phosphory ...[more]