Ontology highlight
ABSTRACT:
SUBMITTER: Artemenko Y
PROVIDER: S-EPMC3427065 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Artemenko Yulia Y Batsios Petros P Borleis Jane J Gagnon Zachary Z Lee Josephine J Rohlfs Meino M Sanséau Doriane D Willard Stacey S SS Schleicher Michael M Devreotes Peter N PN
Proceedings of the National Academy of Sciences of the United States of America 20120730 34
Chemotaxis depends on a network of parallel pathways that coordinate cytoskeletal events to bias cell movement along a chemoattractant gradient. Using a forward genetic screen in Dictyostelium discoideum, we identified the Ste20 kinase KrsB, a homolog of tumor suppressors Hippo and MST1/2, as a negative regulator of cell spreading and substrate attachment. The excessive adhesion of krsB(-) cells reduced directional movement and prolonged the streaming phase of multicellular aggregation. These ph ...[more]