Ontology highlight
ABSTRACT:
SUBMITTER: Mork L
PROVIDER: S-EPMC3290667 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Mork Lindsey L Maatouk Danielle M DM McMahon Jill A JA Guo Jin Jin JJ Zhang Pumin P McMahon Andrew P AP Capel Blanche B
Biology of reproduction 20120214 2
The embryonic origins of ovarian granulosa cells have been a subject of debate for decades. By tamoxifen-induced lineage tracing of Foxl2-expressing cells, we show that descendants of the bipotential supporting cell precursors in the early gonad contribute granulosa cells to a specific population of follicles in the medulla of the ovary that begin to grow immediately after birth. These precursor cells arise from the proliferative ovarian surface epithelium and enter mitotic arrest prior to upreg ...[more]