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In vitro activity of BMS-790052 on hepatitis C virus genotype 4 NS5A.

ABSTRACT: The antiviral profile of BMS-790052, a potent hepatitis C virus (HCV) replication complex inhibitor targeting nonstructural protein NS5A, is well characterized for HCV genotype-1. Here, we report that BMS-790052 inhibits hybrid replicons containing HCV genotype-4 NS5A genes with 50% effective concentrations (EC(50)s) ranging from 7 to 13 pM. NS5A residue 30 was an important site for BMS-790052-selected resistance in the hybrid replicons. Our results support the potential of BMS-790052 as a valuable component of combination therapy for HCV genotype-4 chronic infection.

SUBMITTER: Wang C 

PROVIDER: S-EPMC3294917 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature

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In vitro activity of BMS-790052 on hepatitis C virus genotype 4 NS5A.

Wang Chunfu C   Jia Lingling L   Huang Haichang H   Qiu Dike D   Valera Lourdes L   Huang Xin X   Sun Jin-Hua JH   Nower Peter T PT   O'Boyle Donald R DR   Gao Min M   Fridell Robert A RA  

Antimicrobial agents and chemotherapy 20111227 3

The antiviral profile of BMS-790052, a potent hepatitis C virus (HCV) replication complex inhibitor targeting nonstructural protein NS5A, is well characterized for HCV genotype-1. Here, we report that BMS-790052 inhibits hybrid replicons containing HCV genotype-4 NS5A genes with 50% effective concentrations (EC(50)s) ranging from 7 to 13 pM. NS5A residue 30 was an important site for BMS-790052-selected resistance in the hybrid replicons. Our results support the potential of BMS-790052 as a valua  ...[more]

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