In vitro activity of daclatasvir on hepatitis C virus genotype 3 NS5A.
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ABSTRACT:
SUBMITTER: Wang C
PROVIDER: S-EPMC3535966 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
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In vitro activity of daclatasvir on hepatitis C virus genotype 3 NS5A.
Wang Chunfu C Valera Lourdes L Jia Lingling L Kirk Melissa J MJ Gao Min M Fridell Robert A RA
Antimicrobial agents and chemotherapy 20121022 1
The NS5A replication complex inhibitor daclatasvir (DCV; BMS-790052) inhibits hybrid replicons containing hepatitis C virus (HCV) genotype 3a (HCV3a) NS5A genes with 50% effective concentrations (EC(50)s) ranging from 120 to 870 pM. Selection studies with a hybrid HCV3a replicon identified NS5A residues 31 and 93 as sites for DCV-selected resistance. Our results support the potential use of DCV as a component in combination therapies for HCV3a chronic infection. ...[more]
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