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Nanoparticle hydrophobicity dictates immune response.

ABSTRACT: Understanding the interactions of nanomaterials with the immune system is essential for the engineering of new macromolecular systems for in vivo applications. Systematic study of immune activation is challenging due to the complex structure of most macromolecular probes. We present here the use of engineered gold nanoparticles to determine the sole effect of hydrophobicity on the immune response of splenocytes. The gene expression profile of a range of cytokines (immunological reporters) was analyzed against the calculated log P of the nanoparticle headgroups, with an essentially linear increase in immune activity with the increase in hydrophobicity observed in vitro. Consistent behavior was observed with in vivo mouse models, demonstrating the importance of hydrophobicity in immune system activation.

SUBMITTER: Moyano DF

PROVIDER: S-EPMC3296893 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature

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Nanoparticle hydrophobicity dictates immune response.

Moyano Daniel F DF Goldsmith Meir M Solfiell David J DJ Landesman-Milo Dalit D Miranda Oscar R OR Peer Dan D Rotello Vincent M VM

Journal of the American Chemical Society 20120224 9

Understanding the interactions of nanomaterials with the immune system is essential for the engineering of new macromolecular systems for in vivo applications. Systematic study of immune activation is challenging due to the complex structure of most macromolecular probes. We present here the use of engineered gold nanoparticles to determine the sole effect of hydrophobicity on the immune response of splenocytes. The gene expression profile of a range of cytokines (immunological reporters) was an ...[more]

PMID: 22339432

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