Surfactant protein-D regulates effector cell function and fibrotic lung remodeling in response to bleomycin injury.

ABSTRACT:

Rationale

Surfactant protein (SP)-D and SP-A have been implicated in immunomodulation in the lung. It has been reported that patients with idiopathic pulmonary fibrosis (IPF) often have elevated serum levels of SP-A and SP-D, although their role in the disease is not known.

Objectives

The goal of this study was to test the hypothesis that SP-D plays an important role in lung fibrosis using a mouse model of fibrosis induced by bleomycin (BLM).

Methods

Triple transgenic inducible SP-D mice (iSP-D mice), in which rat SP-D is expressed in response to doxycycline (Dox) treatment, were administered BLM (100 U/kg) or saline subcutaneously using miniosmotic pumps.

Measurements and main results

BLM-treated iSP-D mice off Dox (SP-D off) had increased lung fibrosis compar

SUBMITTER: Aono Y 

PROVIDER: S-EPMC3297103 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature