Nrf2 Regulates the Risk of a Diesel Exhaust Inhalation-Induced Immune Response during Bleomycin Lung Injury and Fibrosis in Mice.
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ABSTRACT:
SUBMITTER: Li YJ
PROVIDER: S-EPMC5372661 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
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Nrf2 Regulates the Risk of a Diesel Exhaust Inhalation-Induced Immune Response during Bleomycin Lung Injury and Fibrosis in Mice.
Li Ying-Ji YJ Shimizu Takako T Shinkai Yusuke Y Hirata Yukiyo Y Inagaki Hirofumi H Takeda Ken K Azuma Arata A Yamamoto Masayuki M Kawada Tomoyuki T
International journal of molecular sciences 20170317 3
The present study investigated the effects of diesel exhaust (DE) on an experimental model of bleomycin (BLM)-induced lung injury and fibrosis in mice. BLM was intravenously administered to both <i>Nrf2</i><sup>+/+</sup> and <i>Nrf2</i><sup>-/-</sup> C57BL/6J mice on day 0. The mice were exposed to DE for 56 days from 28 days before the BLM injection to 28 days after the BLM injection. Inhalation of DE induced significant inhibition of airway clearance function and the proinflammatory cytokine s ...[more]
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