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Common variants at VRK2 and TCF4 conferring risk of schizophrenia.

ABSTRACT: Common sequence variants have recently joined rare structural polymorphisms as genetic factors with strong evidence for association with schizophrenia. Here we extend our previous genome-wide association study and meta-analysis (totalling 7 946 cases and 19 036 controls) by examining an expanded set of variants using an enlarged follow-up sample (up to 10 260 cases and 23 500 controls). In addition to previously reported alleles in the major histocompatibility complex region, near neurogranin (NRGN) and in an intron of transcription factor 4 (TCF4), we find two novel variants showing genome-wide significant association: rs2312147[C], upstream of vaccinia-related kinase 2 (VRK2) [odds ratio (OR) = 1.09, P = 1.9 × 10(-9)] and rs4309482[A], between coiled-coiled domain containing 68 (CCDC68) and TCF4, about 400 kb from the previously described risk allele, but not accounted for by its association (OR = 1.09, P = 7.8 × 10(-9)).

SUBMITTER: Steinberg S 

PROVIDER: S-EPMC3298077 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature

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Common variants at VRK2 and TCF4 conferring risk of schizophrenia.

Steinberg Stacy S   de Jong Simone S   Andreassen Ole A OA   Werge Thomas T   Børglum Anders D AD   Mors Ole O   Mortensen Preben B PB   Gustafsson Omar O   Costas Javier J   Pietiläinen Olli P H OP   Demontis Ditte D   Papiol Sergi S   Huttenlocher Johanna J   Mattheisen Manuel M   Breuer René R   Vassos Evangelos E   Giegling Ina I   Fraser Gillian G   Walker Nicholas N   Tuulio-Henriksson Annamari A   Suvisaari Jaana J   Lönnqvist Jouko J   Paunio Tiina T   Agartz Ingrid I   Melle Ingrid I   Djurovic Srdjan S   Strengman Eric E   Jürgens Gesche G   Glenthøj Birte B   Terenius Lars L   Hougaard David M DM   Ørntoft Torben T   Wiuf Carsten C   Didriksen Michael M   Hollegaard Mads V MV   Nordentoft Merete M   van Winkel Ruud R   Kenis Gunter G   Abramova Lilia L   Kaleda Vasily V   Arrojo Manuel M   Sanjuán Julio J   Arango Celso C   Sperling Swetlana S   Rossner Moritz M   Ribolsi Michele M   Magni Valentina V   Siracusano Alberto A   Christiansen Claus C   Kiemeney Lambertus A LA   Veldink Jan J   van den Berg Leonard L   Ingason Andres A   Muglia Pierandrea P   Murray Robin R   Nöthen Markus M MM   Sigurdsson Engilbert E   Petursson Hannes H   Thorsteinsdottir Unnur U   Kong Augustine A   Rubino I Alex IA   De Hert Marc M   Réthelyi János M JM   Bitter István I   Jönsson Erik G EG   Golimbet Vera V   Carracedo Angel A   Ehrenreich Hannelore H   Craddock Nick N   Owen Michael J MJ   O'Donovan Michael C MC   Ruggeri Mirella M   Tosato Sarah S   Peltonen Leena L   Ophoff Roel A RA   Collier David A DA   St Clair David D   Rietschel Marcella M   Cichon Sven S   Stefansson Hreinn H   Rujescu Dan D   Stefansson Kari K  

Human molecular genetics 20110726 20

Common sequence variants have recently joined rare structural polymorphisms as genetic factors with strong evidence for association with schizophrenia. Here we extend our previous genome-wide association study and meta-analysis (totalling 7 946 cases and 19 036 controls) by examining an expanded set of variants using an enlarged follow-up sample (up to 10 260 cases and 23 500 controls). In addition to previously reported alleles in the major histocompatibility complex region, near neurogranin (N  ...[more]

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