Ontology highlight
ABSTRACT:
SUBMITTER: Jia P
PROVIDER: S-EPMC2933424 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Schizophrenia research 20100724 1-3
Unlike the typical analysis of single markers in genome-wide association studies (GWAS), we incorporated Gene Set Enrichment Analysis (GSEA) and hypergeometric test and combined them using Fisher's combined method to perform pathway-based analysis in order to detect genes' combined effects on mediating schizophrenia. A few pathways were consistently found to be top ranked and likely associated with schizophrenia by these methods; they are related to metabolism of glutamate, the process of apopto ...[more]