Ontology highlight
ABSTRACT:
SUBMITTER: Schrode N
PROVIDER: S-EPMC6778520 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Schrode Nadine N Ho Seok-Man SM Yamamuro Kazuhiko K Dobbyn Amanda A Huckins Laura L Matos Marliette R MR Cheng Esther E Deans P J Michael PJM Flaherty Erin E Barretto Natalie N Topol Aaron A Alganem Khaled K Abadali Sonya S Gregory James J Hoelzli Emily E Phatnani Hemali H Singh Vineeta V Girish Deeptha D Aronow Bruce B Mccullumsmith Robert R Hoffman Gabriel E GE Stahl Eli A EA Morishita Hirofumi H Sklar Pamela P Brennand Kristen J KJ
Nature genetics 20190923 10
The mechanisms by which common risk variants of small effect interact to contribute to complex genetic disorders are unclear. Here, we apply a genetic approach, using isogenic human induced pluripotent stem cells, to evaluate the effects of schizophrenia (SZ)-associated common variants predicted to function as SZ expression quantitative trait loci (eQTLs). By integrating CRISPR-mediated gene editing, activation and repression technologies to study one putative SZ eQTL (FURIN rs4702) and four top ...[more]