Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
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ABSTRACT:
SUBMITTER: Franke A
PROVIDER: S-EPMC3299551 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
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Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
Franke Andre A McGovern Dermot P B DP Barrett Jeffrey C JC Wang Kai K Radford-Smith Graham L GL Ahmad Tariq T Lees Charlie W CW Balschun Tobias T Lee James J Roberts Rebecca R Anderson Carl A CA Bis Joshua C JC Bumpstead Suzanne S Ellinghaus David D Festen Eleonora M EM Georges Michel M Green Todd T Haritunians Talin T Jostins Luke L Latiano Anna A Mathew Christopher G CG Montgomery Grant W GW Prescott Natalie J NJ Raychaudhuri Soumya S Rotter Jerome I JI Schumm Philip P Sharma Yashoda Y Simms Lisa A LA Taylor Kent D KD Whiteman David D Wijmenga Cisca C Baldassano Robert N RN Barclay Murray M Bayless Theodore M TM Brand Stephan S Büning Carsten C Cohen Albert A Colombel Jean-Frederick JF Cottone Mario M Stronati Laura L Denson Ted T De Vos Martine M D'Inca Renata R Dubinsky Marla M Edwards Cathryn C Florin Tim T Franchimont Denis D Gearry Richard R Glas Jürgen J Van Gossum Andre A Guthery Stephen L SL Halfvarson Jonas J Verspaget Hein W HW Hugot Jean-Pierre JP Karban Amir A Laukens Debby D Lawrance Ian I Lemann Marc M Levine Arie A Libioulle Cecile C Louis Edouard E Mowat Craig C Newman William W Panés Julián J Phillips Anne A Proctor Deborah D DD Regueiro Miguel M Russell Richard R Rutgeerts Paul P Sanderson Jeremy J Sans Miquel M Seibold Frank F Steinhart A Hillary AH Stokkers Pieter C F PC Torkvist Leif L Kullak-Ublick Gerd G Wilson David D Walters Thomas T Targan Stephan R SR Brant Steven R SR Rioux John D JD D'Amato Mauro M Weersma Rinse K RK Kugathasan Subra S Griffiths Anne M AM Mansfield John C JC Vermeire Severine S Duerr Richard H RH Silverberg Mark S MS Satsangi Jack J Schreiber Stefan S Cho Judy H JH Annese Vito V Hakonarson Hakon H Daly Mark J MJ Parkes Miles M
Nature genetics 20101201 12
We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the top association signals in 15,694 cases, 14,026 controls and 414 parent-offspring trios. We identified 30 new susceptibility loci meeting genome-wide significance (P < 5 × 10⁻⁸). A series of in silico analyses highlighted particular genes within these loci and, together with manual curation, implicated functionally intere ...[more]
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