Ontology highlight
ABSTRACT:
SUBMITTER: Mitchell BL
PROVIDER: S-EPMC8821634 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Mitchell Brittany L BL Saklatvala Jake R JR Dand Nick N Hagenbeek Fiona A FA Li Xin X Min Josine L JL Thomas Laurent L Bartels Meike M Jan Hottenga Jouke J Lupton Michelle K MK Boomsma Dorret I DI Dong Xianjun X Hveem Kristian K Løset Mari M Martin Nicholas G NG Barker Jonathan N JN Han Jiali J Smith Catherine H CH Rentería Miguel E ME Simpson Michael A MA
Nature communications 20220207 1
Acne vulgaris is a highly heritable skin disorder that primarily impacts facial skin. Severely inflamed lesions may leave permanent scars that have been associated with long-term psychosocial consequences. Here, we perform a GWAS meta-analysis comprising 20,165 individuals with acne from nine independent European ancestry cohorts. We identify 29 novel genome-wide significant loci and replicate 14 of the 17 previously identified risk loci, bringing the total number of reported acne risk loci to 4 ...[more]