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Three-Component One-Pot Synthesis of Highly Functionalized Bis-Indole Derivatives.

ABSTRACT: In this study, we detail the development of a concise and efficient three-component protocol for the regioselective synthesis of highly functionalized bis-indoles through a one-pot, two-step sequential process starting from enaminones 1, indoles 2, and acenaphthylene-1,2-dione 3 that is catalyzed by piperidine and p-methyl benzenesulfonic acid. This protocol has several advantages including simplicity of experimental operation, high efficiency of bond formation, ready availability and low cost of starting materials, environmentally benign conditions, and target molecular diversity.

SUBMITTER: Chen XB 

PROVIDER: S-EPMC6682060 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Three-Component One-Pot Synthesis of Highly Functionalized Bis-Indole Derivatives.

Chen Xue-Bing XB   Xiong Sheng-Li SL   Xie Zhi-Xu ZX   Wang Yong-Chao YC   Liu Wei W  

ACS omega 20190709 7

In this study, we detail the development of a concise and efficient three-component protocol for the regioselective synthesis of highly functionalized bis-indoles through a one-pot, two-step sequential process starting from enaminones <b>1</b>, indoles <b>2</b>, and acenaphthylene-1,2-dione <b>3</b> that is catalyzed by piperidine and <i>p</i>-methyl benzenesulfonic acid. This protocol has several advantages including simplicity of experimental operation, high efficiency of bond formation, ready  ...[more]

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