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One-pot multi-component synthesis of new bis-pyridopyrimidine and bis-pyrimidoquinolone derivatives.

ABSTRACT: A variety of bis-heterocycles such as bis(pyrimido[4,5-b]quinolone), bis(chromeno[3',4':5,6]pyrido[2,3-d]pyrimidine), bis(pyrido[2,3-d:6,5-d']dipyrimidine), and bis(benzo[g]pyrimido[4,5-b]quinolone) derivatives were synthesized via one-pot, multi-component reaction of various 6-aminouracils or 6-aminothiouracils, terephthalaldehyde, and CH-acids such as 4-hydroxycoumarin, dimedone, 2-hydroxy-1,4-naphthoquinone, barbituric acid, and thiobarbituric acid in EtOH as a solvent at reflux. The mild conditions, fast rate of reaction, absence of catalyst, different functional group compatibility, simple operation and work-up involving no chromatographic process, are worth mentioning.

SUBMITTER: Masoumi M

PROVIDER: S-EPMC7536303 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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One-pot multi-component synthesis of new bis-pyridopyrimidine and bis-pyrimidoquinolone derivatives.

Masoumi Milad M Bayat Mohammad M Hosseini Fahimeh Sadat FS

Heliyon 20200901 9

A variety of bis-heterocycles such as bis(pyrimido[4,5-b]quinolone), bis(chromeno[3',4':5,6]pyrido[2,3-d]pyrimidine), bis(pyrido[2,3-d:6,5-d']dipyrimidine), and bis(benzo[g]pyrimido[4,5-b]quinolone) derivatives were synthesized via one-pot, multi-component reaction of various 6-aminouracils or 6-aminothiouracils, terephthalaldehyde, and CH-acids such as 4-hydroxycoumarin, dimedone, 2-hydroxy-1,4-naphthoquinone, barbituric acid, and thiobarbituric ...[more]

PMID: 33033771

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