Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors.
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ABSTRACT:
SUBMITTER: Vance KM
PROVIDER: S-EPMC3302728 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors.
Vance Katie M KM Simorowski Noriko N Traynelis Stephen F SF Furukawa Hiro H
Nature communications 20110101
N-methyl-D-aspartate (NMDA) receptors belong to the family of ionotropic glutamate receptors that mediate a majority of excitatory synaptic transmission. One unique property of GluN1/GluN2D NMDA receptors is an unusually prolonged deactivation time course following the removal of L-glutamate. Here we show, using x-ray crystallography and electrophysiology, that the deactivation time course of GluN1/GluN2D receptors is influenced by the conformational variability of the ligand-binding domain (LBD ...[more]
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