Ontology highlight
ABSTRACT:
SUBMITTER: Grand T
PROVIDER: S-EPMC6233196 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Grand Teddy T Abi Gerges Sarah S David Mélissa M Diana Marco A MA Paoletti Pierre P
Nature communications 20181113 1
GluN3A and GluN3B are glycine-binding subunits belonging to the NMDA receptor (NMDAR) family that can assemble with the GluN1 subunit to form unconventional receptors activated by glycine alone. Functional characterization of GluN1/GluN3 NMDARs has been difficult. Here, we uncover two modalities that have transformative properties on GluN1/GluN3A receptors. First, we identify a compound, CGP-78608, which greatly enhances GluN1/GluN3A responses, converting small and rapidly desensitizing currents ...[more]