Modal gating of GluN1/GluN2D NMDA receptors.
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ABSTRACT:
SUBMITTER: Vance KM
PROVIDER: S-EPMC3690137 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Publications
Modal gating of GluN1/GluN2D NMDA receptors.
Vance Katie M KM Hansen Kasper B KB Traynelis Stephen F SF
Neuropharmacology 20130408
GluN2D-containing NMDA receptors are characterized by an unusually low open probability (0.023), even in the presence of saturating glutamate and glycine. Here, we show that recombinant GluN1/GluN2D NMDA receptors can enter brief periods with exceptionally high open probability (0.65) in excised outside-out and cell-attached single channel recordings. GluN1/GluN2D channels during the enhanced gating mode have similar open durations as occurs outside of the high open probability burst of activity ...[more]
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