Ontology highlight
ABSTRACT:
SUBMITTER: Letellier M
PROVIDER: S-EPMC2729027 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Letellier Mathieu M Wehrlé Rosine R Mariani Jean J Lohof Ann M AM
Proceedings of the National Academy of Sciences of the United States of America 20090803 33
During developmental synaptogenesis, the pre- and postsynaptic cells undergo specific interactions that lead to the establishment of the mature circuit. We have studied the roles of the pre- and postsynaptic cells in establishing this mature innervation by using an in vitro model of synaptic development. We describe climbing fiber (CF)-Purkinje cell (PC) synaptogenesis in cultured mouse hindbrain explants and show that synaptic competition occurs during early development in vitro. By manipulatin ...[more]