Ontology highlight
ABSTRACT:
SUBMITTER: Uranbileg B
PROVIDER: S-EPMC3307327 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20120105 9
In mammalian cells Cdk2 activity during the G(1)-S transition is mainly controlled by p27(KIP1). Although the amount and subcellular localization of p27 influence Cdk2 activity, how Cdk2 activity is regulated during this phase transition still remains virtually unknown. Here we report an entirely new mechanism for this regulation. Cdc6 the AAA+ ATPase, known to assemble prereplicative complexes on chromosomal replication origins and activate p21(CIP1)-bound Cdk2, also activated p27-bound Cdk2 in ...[more]